Microbiome

Table 1 Relative genus abundance associations with future HAZ estimated using multivariable between-within twin regression models for genera with a significant difference in degree centrality between cases and controls

From: Linear growth faltering in infants is associated with Acidaminococcus sp. and community-level changes in the gut microbiota

	Malawi				Bangladesh
Genus	Abundance difference^a	Coefficient (90 % CI)	p value	Adjusted p value	Abundance difference^a	Coefficient (90 % CI)	p value	Adjusted p value
Acidaminococcus	0.40	−0.080 (−0.124, −0.037)	<0.01	0.02	0.30	−0.191 (−0.253, −0.129)	<0.01	<0.01
Acinetobacter ^b					0.00	−0.032 (−0.159, 0.094)	0.68	0.89
Anaerococcus ^b					0.01	−0.182 (−0.915, 0.551)	0.68	0.89
Bacteroides	4.51	0.000 (−0.001, 0.001)	0.67	0.89	0.29	−0.001 (−0.002, 0.001)	0.63	0.89
Blautia	2.51	−0.001 (−0.003, 0.002)	0.64	0.89	5.00	0.001 (0.000, 0.001)	0.07	0.45
Brachyspira	1.03	0.003 (−0.002, 0.007)	0.32	0.89
Chlamydiaceae_uncl	0.37	−0.012 (−0.054, 0.030)	0.65	0.89
Coprococcus	0.35	−0.006 (−0.061, 0.049)	0.87	0.92	4.33	−0.003 (−0.010, 0.003)	0.38	0.89
Geobacillus ^b					0.01	0.266 (−0.154, 0.685)	0.30	0.89
Haemophilus	0.76	0.001 (−0.009, 0.010)	0.92	0.92
Lactococcus ^b					0.04	−0.002 (−0.007, 0.004)	0.59	0.89
Micrococcus ^b					0.46	−0.107 (−2.183, 0.169)	0.16	0.94
Neisseriaceae_uncl	0.22	−0.027 (−0.103,0.048)	0.56	0.89	0.01	0.001 (−0.001, 0.004)	0.46	0.64
Proteus ^b					0.00	−0.002 (−0.037, 0.033)	0.94	0.94
Sarcina ^b					5.00	0.000 (0.000, 0.001)	0.54	0.89

Coefficients are expressed as the average difference in future HAZ per 0.1 % difference in abundance between siblings
90 % CI 90 % confidence interval, HAZ height-for-age z-score
^aMedian difference in relative abundance between siblings in a twin pair
^bModels could not be fit in the Malawi cohort because these genera were only identified in ≤2 samples

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ISSN: 2049-2618

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