The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites

Ana M Misic; Meghan F Davis; Amanda S Tyldsley; Brendan P Hodkinson; Pam Tolomeo; Baofeng Hu; Irving Nachamkin; Ebbing Lautenbach; Daniel O Morris; Elizabeth A Grice

doi:10.1186/s40168-014-0052-7

Microbiome

Table 2 Association of different factors with microbial communities at staphylococcal carriage sites at the baseline visit

From: The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites

Comparison category	Host species	Anatomic site	Beta diversity metric	R statistic and significance
Host species and anatomical site (cat, dog, or human and nares, oral cavity or inguinal/axilla)	All	All	Weighted UniFrac	0.5753***
			Unweighted UniFrac	0.4731***
			Bray-Curtis	0.5803***
			Binary Jaccard	0.5470***
Host species (cat, dog, or human)	All	Nares	Weighted UniFrac	0.4326***
			Unweighted UniFrac	0.2525***
			Bray-Curtis	0.5230***
			Binary Jaccard	0.5378***
Household membership	Cats	Nares	Weighted UniFrac	0.4698*
			Unweighted UniFrac	0.7501**
			Bray-Curtis	0.7776**
			Binary Jaccard	0.9451**
	Cats	Oral cavity	Weighted UniFrac	0.5246**
			Unweighted UniFrac	0.5815**
			Bray-Curtis	0.5714**
			Binary Jaccard	0.6018**
	Dogs	Nares	Weighted UniFrac	0.1786
			Unweighted UniFrac	0.4100*
			Bray-Curtis	0.0363
			Binary Jaccard	0.4170*
	Dogs	Oral cavity	Weighted UniFrac	0.4090**
			Unweighted UniFrac	0.3042**
			Bray-Curtis	0.4372**
			Binary Jaccard	0.5328**
	Humans	Nares	Weighted UniFrac	0.2525*
			Unweighted UniFrac	0.4926**
			Bray-Curtis	0.3203**
			Binary Jaccard	0.5012**
	Humans	Inguinal/axilla	Weighted UniFrac	−0.0178
			Unweighted UniFrac	0.1196
			Bray-Curtis	0.0472
			Binary Jaccard	0.1931*
Index subject status (Yes or no)	Humans	Nares	Weighted UniFrac	0.0558
			Unweighted UniFrac	−0.0774
			Bray-Curtis	0.0807
			Binary-Jaccard	−0.1209
	Humans	Inguinal/axilla	Weighted UniFrac	0.1084
			Unweighted UniFrac	−0.1137
			Bray-Curtis	0.1399
			Binary Jaccard	0.1010
Household pet ownership (Yes or no)	Human	Nares	Weighted UniFrac	0.1466
			Unweighted UniFrac	−0.0579
			Bray-Curtis	0.0507
			Binary Jaccard	−0.0350
	Human	Inguinal/axilla	Weighted UniFrac	−0.0256
			Unweighted UniFrac	0.0495
			Bray-Curtis	−0.0319
			Binary Jaccard	0.1119

Summarized are ANOSIM analyses assessing association of various metadata on microbial community distances measured using weighted and unweighted UniFrac, Bray-Curtis index, and Jaccard index. *p < 0.05, **p < 0.005, and ***p ≤ 0.001 (FDR adjusted values).

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