Distinct microbiomes colonize staphylococcal carriage sites of dogs, cats, and humans. (A) Weighted UniFrac metric principal coordinates analysis (PCoA) comparing the microbiomes of cat oral cavities (red circles), cat nares (red squares), dog oral cavities (green circles), dog nares (green squares), human inguinal creases/axillae (blue triangles), human nares (blue squares), and human healing lesions (blue stars). The grey circles represent the six most abundant genus-level consensus taxonomies (unclassified Moraxellaceae, Corynebacterium, Staphylococcus, unclassified Pasteurellaceae, Moraxella, and Streptococcus) contributing to variation, and size of spheres indicates relative abundance. Percent variation explained by PC1 and PC2 is represented in parentheses by each axis. (B) Alpha diversity characteristics of pet and human Staphylococcus carriage sites, visualized by the weighted UniFrac metric PCoA comparing microbial communities and alpha diversity (Shannon diversity index) overlaid on the same PCoA plot. (C) Shannon diversity index values comparing cat, dog, and human staphylococcal carriage sites are depicted with each circle representing one sample and medians indicated by red lines.