Prolonged use of a proton pump inhibitor reduces microbial diversity: implications for Clostridium difficile susceptibility

Table 1 Statistical significance of observed OTU changes between sample groups

Cohort	T0	T7	T28	T56
T0
T7	0.0117
T28	0.0039	0.0328
T56	0.0328	0.9102	0.1069
CD^a	0.0051	0.0112	0.0829	0.0599

Table of statistical tests between matched-pair healthy subject time intervals to determine the significance of measured differences in observed species counts. Species counts were calculated from samples rarefied to 75,000 reads. Testing for matched-pair healthy samples used one-tailed (alternative = “greater”) Wilcoxon signed rank.
^aNon-matched pair probabilities for groups with C. difficile (CD) were calculated using one-tailed (alternative = “greater”) Wilcoxon rank sum with continuity correction.

ISSN: 2049-2618