Figure 1

Characterization of the fungal communities of sputum samples from CF subjects. (A) Fraction of pyrosequencing reads assigned to each of the top four fungal taxa detected in CF subjects immediately after an exacerbation and before starting an antibacterial therapy (pre) and approximately 2 weeks afterwards (post) or while hospitalized (inter). The legend indicates the color assigned to each indicated fungal species or genus (Malassezia sp. unknown). (B) Relative abundance of all fungal genera, extended to the species level for the clinically important Candida species (colored dots), is plotted against the prevalence of each genus and Candida species in the six CF subject samples (pre- and post-treatment) and show that fungi that are highly abundant in a single patient are also highly prevalent across patients. The colored dots indicate the Candida species and the genus Malassezia that are both highly abundant and highly prevalent and the empty dots represent all remaining fungal genera identified in our study.