Table 1 Predicted upregulated functions in tissue-associated microbiota after anastomosis
From: Intestinal anastomotic injury alters spatially defined microbiome composition and function
KEGG orthology | Description | Pathway/function | Primary contributor | p value |
|---|---|---|---|---|
K03276 | UDP-glucose/galactose:(glucosyl)LPS alpha-1,2-glucosyl/galactosyltransferase [EC:2.4.1.-] | Lipopolysaccharide biosynthesis | Enterobacteriaceae | 0.02 |
K11139 | Hemolysin E | Pore-forming toxin [7] | Enterobacteriaceae | 0.02 |
K03765 | Transcriptional activator of cad operon | The cad operon encodes a system for neutralization of low extracellular pH | Enterobacteriaceae | 0.02 |
K12678 | AIDA-I adhesin-like protein | Autotransporter family porin, mediates bacterial attachment to mammalian cells [8] | Enterobacteriaceae | 0.02 |
K09925 | Hypothetical protein | Â | Â | 0.02 |
K11014 | Cytolethal distending toxin subunit B (CdtB) | Initiates a eukaryotic cell cycle block at the G2 stage prior to mitosis, CdtB potentiates a cascade leading to cell cycle block [9] | Enterobacteriaceae | 0.02 |
K11015 | Cytolethal distending toxin subunit C (CdtC) | CdtC and CdtA function as dimeric subunits, which bind CdtB and delivers it to the mammalian cell interior | Enterobacteriaceae | 0.02 |
K11013 | Cytolethal distending toxin subunit A (CdtA) | Same as above | Enterobacteriaceae | 0.02 |
K11264 | Methylmalonyl-CoA decarboxylase [EC:4.1.1.41] | Propanoate metabolism | Enterobacteriaceae | 0.02 |
K13244 | c-di-GMP-specific phosphodiesterase [EC:3.1.4.52] | Hydrolases acting on ester bonds | Enterobacteriaceae | 0.02 |
K03459 | Formate transporter (focB) | Electrochemical potential-driven transporters | Enterobacteriaceae | 0.02 |
K07354 | Outer membrane usher protein (sfmD) | Bacterial motility proteins [11] | Enterobacteriaceae | 0.02 |
K07355 | Fimbrial-like protein (sfmF) | Bacterial motility proteins | Enterobacteriaceae | 0.02 |
K07352 | Type 1 fimbrial protein (sfmA) | Bacterial motility proteins | Enterobacteriaceae | 0.02 |
K07353 | Fimbrial chaperone protein | Bacterial motility proteins | Enterobacteriaceae | 0.02 |
K12985 | (Galactosyl)LPS 1,2-glucosyltransferase [EC:2.4.1.-] | Lipopolysaccharide biosynthesis proteins | Enterobacteriaceae | 0.02 |
K10708 | Fructoselysine 6-phosphate deglycase [EC:3.5.-.-] | Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds | Enterobacteriaceae | 0.02 |
K11008 | Cytotoxic necrotizing factor 1 (cnf1) | Blocks cell cycle G2/M transition in uroepithelial cells [10] | Enterobacteriaceae | 0.02 |
K11920 | AraC family transcriptional regulator (envY) | DNA-binding transcriptional regulator | Enterobacteriaceae | 0.02 |
K13285 | Invasin B | Enterobacteriaceae | 0.03 | |
K08605 | Coccolysin [EC:3.4.24.30] (gelE) | Enterococcus | 0.03 |