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Table 1 Predicted upregulated functions in tissue-associated microbiota after anastomosis

From: Intestinal anastomotic injury alters spatially defined microbiome composition and function

KEGG orthology Description Pathway/function Primary contributor p value
K03276 UDP-glucose/galactose:(glucosyl)LPS alpha-1,2-glucosyl/galactosyltransferase [EC:2.4.1.-] Lipopolysaccharide biosynthesis Enterobacteriaceae 0.02
K11139 Hemolysin E Pore-forming toxin [7] Enterobacteriaceae 0.02
K03765 Transcriptional activator of cad operon The cad operon encodes a system for neutralization of low extracellular pH Enterobacteriaceae 0.02
K12678 AIDA-I adhesin-like protein Autotransporter family porin, mediates bacterial attachment to mammalian cells [8] Enterobacteriaceae 0.02
K09925 Hypothetical protein    0.02
K11014 Cytolethal distending toxin subunit B (CdtB) Initiates a eukaryotic cell cycle block at the G2 stage prior to mitosis, CdtB potentiates a cascade leading to cell cycle block [9] Enterobacteriaceae 0.02
K11015 Cytolethal distending toxin subunit C (CdtC) CdtC and CdtA function as dimeric subunits, which bind CdtB and delivers it to the mammalian cell interior Enterobacteriaceae 0.02
K11013 Cytolethal distending toxin subunit A (CdtA) Same as above Enterobacteriaceae 0.02
K11264 Methylmalonyl-CoA decarboxylase [EC:] Propanoate metabolism Enterobacteriaceae 0.02
K13244 c-di-GMP-specific phosphodiesterase [EC:] Hydrolases acting on ester bonds Enterobacteriaceae 0.02
K03459 Formate transporter (focB) Electrochemical potential-driven transporters Enterobacteriaceae 0.02
K07354 Outer membrane usher protein (sfmD) Bacterial motility proteins [11] Enterobacteriaceae 0.02
K07355 Fimbrial-like protein (sfmF) Bacterial motility proteins Enterobacteriaceae 0.02
K07352 Type 1 fimbrial protein (sfmA) Bacterial motility proteins Enterobacteriaceae 0.02
K07353 Fimbrial chaperone protein Bacterial motility proteins Enterobacteriaceae 0.02
K12985 (Galactosyl)LPS 1,2-glucosyltransferase [EC:2.4.1.-] Lipopolysaccharide biosynthesis proteins Enterobacteriaceae 0.02
K10708 Fructoselysine 6-phosphate deglycase [EC:3.5.-.-] Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds Enterobacteriaceae 0.02
K11008 Cytotoxic necrotizing factor 1 (cnf1) Blocks cell cycle G2/M transition in uroepithelial cells [10] Enterobacteriaceae 0.02
K11920 AraC family transcriptional regulator (envY) DNA-binding transcriptional regulator Enterobacteriaceae 0.02
K13285 Invasin B Bacterial invasion of epithelial cells [12, 17] Enterobacteriaceae 0.03
K08605 Coccolysin [EC:] (gelE) Metallopeptidases [13, 14] Enterococcus 0.03