Figure 4

Intestinal bacterial taxa exhibiting significant differences in abundance between Clostridium difficile infection (CDI) cases and control subjects. The scatter plots show log-transformed 16S sequence counts for the corresponding bacterial (A) phylum or (B- D) family in cases (n = 25) versus controls (n = 25). Results are presented for both V1-V3 and V3-V5 sequence sets. Patients with the lowest degree of intestinal biodiversity (n = 6; all of these patients are cases) are shown with open circles. Horizontal lines represent the median and interquartile range. P values were determined by logistic regression.