Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

McHardy, Ian H; Goudarzi, Maryam; Tong, Maomeng; Ruegger, Paul M; Schwager, Emma; Weger, John R; Graeber, Thomas G; Sonnenburg, Justin L; Horvath, Steve; Huttenhower, Curtis; McGovern, Dermot PB; Fornace, Albert J; Borneman, James; Braun, Jonathan

doi:10.1186/2049-2618-1-17

Table 4 Analysis of metabolite-associated microbial communities

From: Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

Metabolite mass and retention time	Putative ID	Colonic region	Correlated OTUs, number (q<0.2)	Total branch length	Association type	Average positive correlation	Average negative correlation	Number of correlations >0.2	Number of correlations <−0.2
Magenta module	Multiple	Cecum	120	16.58	All positive	0.16^***	−0.14^***	2182^***	1930^***
Green yellow module	Multiple	Cecum	94	16.48	Mostly positive	0.14^***	−0.14^***	1170^***	1126^***
342.2631 m/z RT = 4.2272	trans-2-Dodecenoylcarnitine	Cecum	45	11.21	Mostly negative	0.16^***	−0.14^**	290^**	298^***
Pink module	Multiple	Cecum	31	9.17	Mostly negative	0.13	−0.11	90	58
Brown module	Multiple	Cecum	23	6.81	All positive	0.18^**	−0.12	88^**	42
386.2897 m/z RT = 4.3619	3-Hydroxy-cis-5-tetradecenoylcarnitine	Cecum	19	6.18	Mostly negative	0.13	−0.1	28	20
230.1845 m/z RT = 0.4078	N1,N8-diacetylspermidine	Cecum	17	6	All negative	0.32^***	−0.29^***	102^***	84^***
596.3475 m/z RT = 3.04	?	Sigmoid	61	8.97	All positive	0.14^**	−0.14^***	442^**	406^**
595.3469 m/z RT = 3.0469	L-Urobilin	Sigmoid	58	10.5	All positive	0.13	−0.12^*	326	322^*
593.3309 m/z RT = 3.0247	I-Urobilinogen	Sigmoid	54	9	Mostly positive	0.15^***	−0.14^***	384^**	344^**
613.3011 m/z RT = 3.0293	Harderoporphyrinogen	Sigmoid	52	9.02	All positive	0.15^***	−0.14^***	376^***	356^***
605.3348 m/z RT = 3.3185	(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)	Sigmoid	43	10.1	Mostly positive	0.15^*	−0.13^*	222^*	194^*
591.3203 m/z RT = 3.0304	Mesobilirubinogen	Sigmoid	37	9.03	Mostly positive	0.13	−0.12^*	152^*	122
Salmon module	Multiple	Sigmoid	37	8	Mostly positive	0.15^*	−0.14^**	184^**	160^**
100.0761 m/z RT = 0.3093	2-Hydroxy-2-methylbutanenitrile	Sigmoid	32	8.37	22% Negative, 78% positive	0.21^***	−0.16^***	178^**	196^***
673.3209 m/z RT = 3.3132	?	Sigmoid	30	7.93	Mostly positive	0.15^*	−0.14^*	128^**	110^**
434.1867 m/z RT = 0.6621	?	Sigmoid	26	6.54	30% Positive, 70% negative	0.28^***	−0.21^***	160^***	162^***
619.3474 m/z RT = 3.6896	?	Sigmoid	25	9.13	Mostly positive	0.13	−0.13^*	76^*	48
124.0395 m/z RT = 0.3735	Nicotinate	Sigmoid	21	7.47	Mostly negative	0.18^**	−0.11	58^*	30
615.3154 m/zRT = 3.0227	Mesobilirubinogen	Sigmoid	18	6.31	All positive	0.1	−0.08	6	2
Midnight blue module	Multiple	Sigmoid	18	6	All positive	0.1	−0.08	14	12

Significance values: ^***P ≤0.001, ^**P ≤0.01, ^*P ≤0.05.
Total branch length is the sum of all branch lengths from Phylogenetic (Newick) trees containing the corresponding operational taxonomic units (OTUs). Retention time (RT) is provided in minutes.

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ISSN: 2049-2618

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