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Table 4 Analysis of metabolite-associated microbial communities

From: Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

Metabolite mass and retention time Putative ID Colonic region Correlated OTUs, number (q<0.2) Total branch length Association type Average positive correlation Average negative correlation Number of correlations >0.2 Number of correlations <−0.2
Magenta module Multiple Cecum 120 16.58 All positive 0.16*** −0.14*** 2182*** 1930***
Green yellow module Multiple Cecum 94 16.48 Mostly positive 0.14*** −0.14*** 1170*** 1126***
342.2631 m/z RT = 4.2272 trans-2-Dodecenoylcarnitine Cecum 45 11.21 Mostly negative 0.16*** −0.14** 290** 298***
Pink module Multiple Cecum 31 9.17 Mostly negative 0.13 −0.11 90 58
Brown module Multiple Cecum 23 6.81 All positive 0.18** −0.12 88** 42
386.2897 m/z RT = 4.3619 3-Hydroxy-cis-5-tetradecenoylcarnitine Cecum 19 6.18 Mostly negative 0.13 −0.1 28 20
230.1845 m/z RT = 0.4078 N1,N8-diacetylspermidine Cecum 17 6 All negative 0.32*** −0.29*** 102*** 84***
596.3475 m/z RT = 3.04 ? Sigmoid 61 8.97 All positive 0.14** −0.14*** 442** 406**
595.3469 m/z RT = 3.0469 L-Urobilin Sigmoid 58 10.5 All positive 0.13 −0.12* 326 322*
593.3309 m/z RT = 3.0247 I-Urobilinogen Sigmoid 54 9 Mostly positive 0.15*** −0.14*** 384** 344**
613.3011 m/z RT = 3.0293 Harderoporphyrinogen Sigmoid 52 9.02 All positive 0.15*** −0.14*** 376*** 356***
605.3348 m/z RT = 3.3185 (23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide) Sigmoid 43 10.1 Mostly positive 0.15* −0.13* 222* 194*
591.3203 m/z RT = 3.0304 Mesobilirubinogen Sigmoid 37 9.03 Mostly positive 0.13 −0.12* 152* 122
Salmon module Multiple Sigmoid 37 8 Mostly positive 0.15* −0.14** 184** 160**
100.0761 m/z RT = 0.3093 2-Hydroxy-2-methylbutanenitrile Sigmoid 32 8.37 22% Negative, 78% positive 0.21*** −0.16*** 178** 196***
673.3209 m/z RT = 3.3132 ? Sigmoid 30 7.93 Mostly positive 0.15* −0.14* 128** 110**
434.1867 m/z RT = 0.6621 ? Sigmoid 26 6.54 30% Positive, 70% negative 0.28*** −0.21*** 160*** 162***
619.3474 m/z RT = 3.6896 ? Sigmoid 25 9.13 Mostly positive 0.13 −0.13* 76* 48
124.0395 m/z RT = 0.3735 Nicotinate Sigmoid 21 7.47 Mostly negative 0.18** −0.11 58* 30
615.3154 m/zRT = 3.0227 Mesobilirubinogen Sigmoid 18 6.31 All positive 0.1 −0.08 6 2
Midnight blue module Multiple Sigmoid 18 6 All positive 0.1 −0.08 14 12
  1. Significance values: ***P ≤0.001, **P ≤0.01, *P ≤0.05.
  2. Total branch length is the sum of all branch lengths from Phylogenetic (Newick) trees containing the corresponding operational taxonomic units (OTUs). Retention time (RT) is provided in minutes.
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