Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

Table 2 Network features of inter-omic analysis

	q<0.2		q<0.1
	Cecum	Sigmoid	Cecum	Sigmoid
Total interactions, number	605	1056	442	805
Unique microbial nodes, number	338	372	297	342
Unique metabolic nodes, number	95	147	87	142
Ratio of Firmicutes OTUs with metabolic correlations	34%	34%	30%	31%
Ratio of Bacteroidetes OTUs with metabolic correlations	18%	18%	16%	18%
Ratio of Proteobacteria OTUs with metabolic correlations	12%	24%	11%	22%
Ratio of Actinobacteria OTUs with metabolic correlations	25%	54%	20%	54%
Ratio of Tenericutes OTUs with metabolic correlations	24%	24%	19%	24%
Average number of interactions per OTU	1.8	2.8	1.5	2.4
Average number of interactions per metabolite	6.4^**	7.2^**	5.1^**	5.7^**

^**Mann–Whitney test, P <2 × 10^-16 for comparison between interactions of operational taxonomic units (OTUs) and metabolites.

ISSN: 2049-2618