|
Feature
|
Transwell Inserts
|
SHIME[109]
|
M-SHIME[110]
|
TIM1[111]
|
TIM2[112]
|
CCS[113]
|
Gut-on-a-Chip[44]
|
|---|
|
Human cell culture
a
|
+b
|
-
|
-
|
-
|
-
|
+b
|
++b
|
|
GIT microbiota culture
|
-
|
+
|
+
|
-
|
+
|
-
|
-
|
|
Anaerobic conditions for microbes
|
-
|
+
|
+
|
+
|
+
|
+
|
-
|
|
Mucin
|
+
|
-
|
+
|
-
|
-
|
-
|
-
|
|
pH measurement
|
-
|
+
|
+
|
+
|
+
|
+
|
-
|
|
Throughput
|
+
|
-
|
-
|
-
|
-
|
-
|
+
|
- aThe models involving the possibility to incorporate human cells can be subjected to Trans-epithelial Electric Resistance (TEER) measurements (except the model CCS).
- b+, co-culture for 3 to 6 h; ++, co-culture for >1 week.
- CCS, continuous culture system; GIT, gastrointestinal tract; M-SHIME, Mucus-Simulator of the Human Intestinal Microbial Ecosystem; SHIME, Simulator of the Human Intestinal Microbial Ecosystem; TIM1, model simulating the stomach and small intestine; TIM2, model simulating the large intestine.
