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Table 3 Microbial and metabolite predictors of NEC

From: Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants

Criteria

Description

NEC

Controls

P a

Predictive value (c)

Sensitivity

Specificity

1

High Firmicutes dysbiosis (≥98%, days 4 to 9)

4/9 (44%)

0/18 (0)

0.007

72%

44%

100%

2

No Propionibacterium (days 4 to 9)

9/9 (100%)

8/18 (44%)

0.009

78%

100%

56%

3

High Proteobacteria dysbiosis (≥90%, days 10 to 16)

6/9 (67%)

8/19 (42%)

0.420

62%

67%

58%

4

Dysbiosis (criterion 1 or 3)

7/7 (100%)

8/16 (50%)

0.052

75%

100%

50%

5

Combined criteria 2 and 4 (no Propionibacterium + dysbiosis)

7/7 (100%)

4/16 (25%)

0.001

88%

100%

75%

6

Urinary alanine:histidine ratio >4 (days 4 to 9)

9/11 (82%)

5/20 (25%)

0.007

78%

82%

75%

  1. aP values based on Fisher’s exact test. The variations in denominator are due to varying sample availability.