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Table 3 Microbial and metabolite predictors of NEC

From: Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants

Criteria Description NEC Controls P a Predictive value (c) Sensitivity Specificity
1 High Firmicutes dysbiosis (≥98%, days 4 to 9) 4/9 (44%) 0/18 (0) 0.007 72% 44% 100%
2 No Propionibacterium (days 4 to 9) 9/9 (100%) 8/18 (44%) 0.009 78% 100% 56%
3 High Proteobacteria dysbiosis (≥90%, days 10 to 16) 6/9 (67%) 8/19 (42%) 0.420 62% 67% 58%
4 Dysbiosis (criterion 1 or 3) 7/7 (100%) 8/16 (50%) 0.052 75% 100% 50%
5 Combined criteria 2 and 4 (no Propionibacterium + dysbiosis) 7/7 (100%) 4/16 (25%) 0.001 88% 100% 75%
6 Urinary alanine:histidine ratio >4 (days 4 to 9) 9/11 (82%) 5/20 (25%) 0.007 78% 82% 75%
  1. aP values based on Fisher’s exact test. The variations in denominator are due to varying sample availability.