Criteria | Description | NEC | Controls | P a | Predictive value (c) | Sensitivity | Specificity |
---|---|---|---|---|---|---|---|
1 | High Firmicutes dysbiosis (≥98%, days 4 to 9) | 4/9 (44%) | 0/18 (0) | 0.007 | 72% | 44% | 100% |
2 | No Propionibacterium (days 4 to 9) | 9/9 (100%) | 8/18 (44%) | 0.009 | 78% | 100% | 56% |
3 | High Proteobacteria dysbiosis (≥90%, days 10 to 16) | 6/9 (67%) | 8/19 (42%) | 0.420 | 62% | 67% | 58% |
4 | Dysbiosis (criterion 1 or 3) | 7/7 (100%) | 8/16 (50%) | 0.052 | 75% | 100% | 50% |
5 | Combined criteria 2 and 4 (no Propionibacterium + dysbiosis) | 7/7 (100%) | 4/16 (25%) | 0.001 | 88% | 100% | 75% |
6 | Urinary alanine:histidine ratio >4 (days 4 to 9) | 9/11 (82%) | 5/20 (25%) | 0.007 | 78% | 82% | 75% |