Ecological patterns and processes of temporal turnover within lung infection microbiota

Gavillet, Helen; Hatfield, Lauren; Jones, Andrew; Maitra, Anirban; Horsley, Alexander; Rivett, Damian; van der Gast, Christopher

doi:10.1186/s40168-024-01780-6

Microbiome

Table 1 Clinical characteristics of individual (A) paediatric and (B) adult patients

From: Ecological patterns and processes of temporal turnover within lung infection microbiota

	Age^b	Sex	CFTR Genotype1	CFTR Genotype2	CF-related diabetes	Pancreatic insufficiency	%FEV₁^c	SD	Exacerbations^d
(A)
201^a	12	Female	F508del	G551D	No	Insufficient	84.4	2.7	3
203	6	Female	F508del	F508del	No	Insufficient	100.2	10.7	1
212	9	Female	F508del	F508del	No	Insufficient	83.9	6.3	4
213	6	Male	F508del	F508del	No	Insufficient	82.3	15.7	3
216	9	Female	SN549N	SN549N	No	Insufficient	117.8	5.2	1
217	8	Male	F508del	G542X	No	Insufficient	100.4	2.7	0
218	11	Male	F508del	F508del	No	Insufficient	89.6	6.6	2
219	8	Male	F508del	R56OT	No	Insufficient	98.7	1.4	0
223	8	Male	F508del	S1235R	No	Sufficient	110.0	1.7	0
228	6	Male	F508del	R553X	No	Insufficient	99.8	6.2	0
233	15	Male	F508del	F508del	No	Insufficient	71.2	9.9	1
240	11	Female	F508del	F508del	No	Insufficient	60.6	6.3	1
242^a	6	Female	F508del	G551D	No	Insufficient	74.7	8.6	2
245	6	Male	F508del	F508del	No	Insufficient	92.0	14.2	3
246	9	Female	3849 + 10kbC > T	3849 + 10kbC > T	No	Sufficient	91.0	9.1	2
(B)
101	22	Male	R334W	R75X	No	Sufficient	64.2	2.1	7
103	22	Male	F508del	3849 + 10kbC > T	No	Sufficient	79.7	7.9	1
104	28	Male	3849 + 10kbC > T	3849 + 10kbC > T	No	Sufficient	77.9	7.5	2
106	19	Male	F508del	F508del	No	Insufficient	57.2	8.0	8
108	35	Male	F508del	F508del	No	Insufficient	60.7	1.5	2
110	28	Female	F508del	F508del	No	Insufficient	120.1	2.7	1
112	24	Male	F508del	F508del	No	Sufficient	93.2	4.5	1
113	21	Female	F508del	Delexon2-3	No	Insufficient	58.1	1.4	3
114	21	Male	F508del	F508del	No	Insufficient	87.1	1.9	0
116	24	Male	R117H	S549N	No	Sufficient	99.6	2.1	0
118	25	Female	F508del	F508del	No	Insufficient	73.8	4.2	3
119	20	Female	R553X	2622 + 1G- > A	Yes	Insufficient	47.9	2.9	3
120	19	Male	F508del	F508del	No	Insufficient	78.6	3.3	0
121	29	Male	F508del	R117H	No	Sufficient	92.9	3.7	1
140	17	Male	F508del	2622 + 1G > A	No	Sufficient	47.3	6.9	6

^aPatients receiving Ivacaftor CF transmembrane conductance regulator (CFTR) modulator therapy
^bAge in years at the start of the study
^cMean lung function ± standard deviation (SD) over the course of the study
^dNumber of acute pulmonary exacerbations experienced over the course of the study

Back to article page

ISSN: 2049-2618

Contact us

General enquiries: journalsubmissions@springernature.com