Fig. 3

The temporal dynamics of antibiotic resistance genes (ARGs) and their interactions. A Heatmap depicted the age-associated ARGs identified by the LEfSe algorithm. The heat map shows the average relative abundances of ARGs on a log scale. The color of cells from purple to red corresponds to the relative abundance of ARGs from low to high. B A network analysis of the interactions among ARGs at different ages. The SparCC algorithm was employed for network analysis. The nodes (resistance genes, ARGs) were colored by antibiotics at the group level of MEGARes 2.0, and the font color of ARGs represents the age-associated signatures identified by the LEfSe