Fig. 6
From: Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Simpson’s diversity of conventional and gnotobiotic zebrafish decreases but recovers after loperamide treatment. Alpha-diversity indices calculated at each timepoint for control water, DMSO, and loperamide-treated samples for A–C 16S rRNA gene amplicon data at the ASV level in conventional fish (n = 5 fish) and D–F CFUs per strain in mix5-colonized fish (n = 3–4 fish). A and D Simpson’s index (H). B and E Observed richness (Sobs) and C and F Pielou’s evenness (H/log(Sobs) are shown. Each point represents a single zebrafish with boxplots shown per condition. *p < 0.05 for loperamide treatment, compared to DMSO. Wilcoxon test