Fig. 1
From: Salivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer
Oral microbiome decreases in diversity and richness after treatment of SCC. A Workflow schematic of the entire study, including the sample collection, main methods, and comparisons. B Nonmetric multidimensional scaling (NMDS) ordination based on θYC distances for patients pre- and post-treatment. Diversity (C) and richness (D) of the salivary microbiome at time 0 (pre-treatment) versus 6 months (post-treatment). E Relative abundance of different phyla at 0 and 6 months. F Bacterial family members that are > 0.1% in relative abundance and significantly different between pre- and post-treatment saliva (adjusted p < 0.05). G Volcano plot indicating significantly different OTUs between 0 and 6 months based on ALDEx2 analysis (adjusted p < 0.05). H Most differentially abundant PICRUSt-predicted KEGG pathways between pre- and post-treatment groups based on LEfSe analysis (LDA cutoff of 2.5). *p < 0.05, ***p < 0.001, and ****p < 0.0001