Skip to main content
Fig. 4 | Microbiome

Fig. 4

From: Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

Fig. 4

Disturbed gut microbiota and reduced IPA production in PCE-induced IUGR rats. A Heatmap of amino acids in colon content. B Tryptophan level in colon content. C IPA levels in different samples. D Correlations between the time spent in target zone or marble burying index and the IPA level in hippocampal tissue. E Schematic of the experimental design in infant cohort. F Body weight of the male infants. G Serum IPA level in the male infants. H Correlation between the serum IPA levels and the body weight of male infants. I Alpha diversity represented by the Simpson index and the Shannon index. J Beta diversity as shown by the PCoA plot. An ellipse represents the 68% confidence interval of microbial distribution in each group. K LEfSe of differentiating genera or species in gut microbiota between groups (LDA > 3). L DNA level of fldC in colon content. Dots in panels represent individual samples. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001

Back to article page

Microbiome

ISSN: 2049-2618

Contact us