Fig. 7From: Host genetic variation in mucosal immunity pathways influences the upper airway microbiomeIngenuity Pathway Analysis (IPA) interaction networks. Networks show genes near nasal mbQTLs are enriched for mucosal immunity pathways. Two significant networks (p < 10−25) are presented. a Network one is centered on SMAD2 and ERK1/2 (p < 10−43; 21 genes). b Network two is a highly connected network centered on IL2RA, STAT5a/b, and IL12, among others. This network contains many of the key regulators of mucosal immunity (p < 10−29; 17 genes). Node color represents genes near microbiome QTL associations in the nasal vestibule (blue) or in the nasopharynx (green); open symbols are genes added by IPA. Edges represent direct (solid) and indirect (dashed) interactions in the IPA Knowledge Base database. Node shapes correspond to functional classes of gene products: concentric circles for groups or complexes, diamonds for enzymes, rectangles for transcriptional regulators or modulators, ovals for trans-membrane receptors, and circles for otherBack to article page